BioAssay Systems’ signal transduction and drug screening services are for evaluating changes in cell signaling as a result of exposure to test compounds. The services allow the screening of phosphorylation status modulators in important cell signalling pathways.
We routinely determine the test compound’s reactivity with different cell species, phosphorylation kinetics and the IC50 of activation or inhibition of the cellular pathway.
BioAssay System’s ADMET services are ideal for early stage drug discovery and specialized for evaluating test compounds as drug candidates. Screen for leads by testing for absorption, distribution, metabolism, excretion, and toxicity.
Rommel Mallaria, Elissa Swearingenb, Wei Liu, Arnold Ow, Stephen W. Young and Shu-Gui Huang* (2003) “A Generic High- throughput Screening Assay for Kinases: Protein Kinase A as an Example”. J. Biomol. Screen. 8: 198-204.
Catherine A. Hong, Elissa Swearingen, Rommel Mallari, Xiong Gao, Zhaodan Cao, Anne North, Stephen W. Young and Shu-Gui Huang* (2003) “Development of A High-Throughput Time-Resolved Fluorescence Resonance Energy Transfer Assay for TRAF6 Ubiquitin Polymerization”. Assay and Drug Development Technologies 1: 175-180.
Shu-Gui Huang* (2002) “Development of A High-throughput Screening Assay for Mitochondrial Membrane Potential in Living Cells”. J. Biomol. Screen. 7: 383-389.
Ellyn Farrelly, M. Catherine Amaral, Lisa Marshall and Shu-Gui Huang* (2001) A high-throughput assay for mitochondrial membrane potential in permeabilized yeast cells. Analytical Biochemistry 293(2):269-276.
Tony Smith, John Chan, Donna Oksenberg, Roman Urfer, Dave Wexler, Arnie Ow, Liping Gao, Alanna McAlorum, and Shu-Gui Huang* (2004). A High-Throughput Turbidometric Assay for Screening Inhibitors of Protein Disulfide Isomerase Activity. J. Biomol. Screen. 9(7): 614-620.
David S. Wexler, Liping Gao, Francisco Anderson, Arnold Ow, Laszlo Nadasdi, Alanna McAlorum, Roman Urfer, and Shu-Gui Huang* (2005). “Linking Solubility and Permeability Assays for Maximum Throughput and Reproducibility”. J. Biomol. Screen. 10(4): 383-390.
Shu-Gui Huang (2005) “Progress from HTS to HTL: Current Strategies in Drug Lead Discovery” Review article in Trends in Pharmaceutical Research 1: 5-10.
David S. Wexler, Shu-Gui Huang, Roman Urfer (2004). “Replumbing the Pipeline: A small, biopharmaceutical company’s strategy for integrating lead optimization and ADMET screening”. Current Drug Discovery, May 2004: 35-38.
Songzhu An, Gene Cutler, Jack Jiagang Zhao, Shu-Gui Huang, Hui Tian, Wanbo Li, Lingming Liang, Mike Rich, Amy Bakleh, Juan Du, Jin-Long Chen and Kang Dai (2001) Identification and Characterization of a melanin-concentrating hormone receptor. Proc. Natl. Acad. Sci. 98: 7576-7581.
Shu-Gui Huang, Donna Oksenberg, Roman Urfer (2005). “High-throughput Turbidometric Assay for Screening Inhibitors of Protein Disulfide Isomerase Activity”. US 6,977,142.