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EnzyFluo™ Farnesyltransferase Inhibitor Screening Kit


  • For high-throughput screening of FTase inhibitors and evaluation of drug modulators.

Key Features

  • Safe. Non-radioactive assay.
  • Homogeneous and convenient. “Mix-incubate-measure” type assay. No wash and reagent transfer steps are involved.
  • High-throughput. A Z’-factor of 0.8 and higher is routinely observed in a 384-well format. Can be readily automated to assay thousands of samples per day.


  • FL340/550 nm


  • Compounds that affect farnesyltransferase activity


  • All


  • 60 min


  • 400 tests in 384well plate

Detection Limit

  • NA

Shelf Life

  • 6 months

More Details

FARNESYLTRANSFERASE (FTase, EC catalyzes the transfer of a farnesyl group from farnesyl pyrophosphate to the cysteine residue of the C-terminus of target proteins. When not properly regulated, farnesylated proteins, including the Ras superfamily of small GTPases, can lead to developmental disorders and cancer. Simple, direct and high-throughput inhibitor screening assays find wide applications for oncology research. BioAssay Systems’ EIFT-400 assay kit provides a convenient fluorimetric method to screen for potential FTase inhibitors. In this assay, FTase reacts with farnesyl pyrophosphate and a dansyl-peptide substrate with measurable fluorescence at λem/ex = 340/550 nm. Inhibition is determined by the decrease in fluorescence.

Weight 1 lbs
Dimensions 9 × 6 × 5 in


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