The heme assay detects the total heme content in the sample, including the heme in hemoglobin.
We have not specifically tested it, but it is highly likely that our heme assay will detect &beta:-hematin and protophorphyrin with the same efficiency as heme, and that it is not possible to distinguish between the variants.
Lapping-Carr, G., et al (2020). Circulating extracellular vesicles from patients with acute chest syndrome disrupt adherens junctions between endothelial cells. Pediatric Research. Assay: Heme in human plasma.
Li, H., et al (2020). SLC46A1 contributes to hepatic iron metabolism by importing heme in hepatocytes. Metabolism, 110, 154306. Assay: Heme in mouse serum.
Aggarwal, S., et al (2020). Heme attenuates endogenous opioid levels in leukocytes of HIV positive individuals with chronic widespread pain. Assay: Heme in human and mouse plasma.
Dos Santos, L. I., et al (2021). Disrupted iron metabolism and mortality during co-infection with malaria and an intestinal Gram-negative Extracellular pathogen. Cell Reports, 34(2), 108613. Assay: Heme in mouse plasma.
Keleku-Lukwete, N., et al (2019). Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice. Blood Advances, 3(8), 1285-1297. Assay: Heme in mouse plasma.
Yang, X., et al (2020). Heme is involved in the systemic inflammatory response following radiofrequency ablation of hepatic hemangiomas. Assay: Heme in human serum.
Poillerat, V., et al (2020). Hemopexin as an inhibitor of hemolysis-induced complement activation. Frontiers in Immunology, 11. Assay: Heme in mouse plasma.
Koike, R., et al. (2020). Heat-killed Fusobacterium nucleatum triggers varying heme-related inflammatory and stress responses depending on primary human respiratory epithelial cell type. Molecules, 25(17), 3839. Assay: Heme in cell media.
Santaterra, V. A., et al (2020). Endothelial barrier integrity is disrupted in vitro by heme and by serum from sickle cell disease patients. Frontiers in Immunology, 11 Assay: Heme in human serum.
Aggarwal, S., Jilling, T., Doran, S., Ahmad, I., Eagen, J. E., Gu, S. & Patel, R. P. (2019). Phosgene Inhalation Causes Hemolysis and Acute Lung Injury. Toxicology Letters. 521724. Assay: Heme in mice blood.
Keleku-Lukwete, N., Suzuki, M., Panda, H., Otsuki, A., Katsuoka, F., Saito, R. & Yamamoto, M. (2019). Nrf2 activation in myeloid cells and endothelial cells differentially mitigates sickle cell disease pathology in mice. Blood advances, 3(8), 1285-1297. Assay: Heme in mice plasma.
Li, X., Wang, X., & Snyder, M. P. (2019). Metformin affects heme function as a possible mechanism of action. G3: Genes, Genomes, Genetics, 9(2), 513-522. Assay: Heme in yeast cells.
Belcher, J. D., Chen, C., Nguyen, J., Abdulla, F., Zhang, P., Nguyen, H. & Nath, K. A. (2018). Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. PloS one, 13(4), e0196455. Assay: Heme in mice plasma.
Cruz, L. A., Barral-Netto, M., & Andrade, B. B. (2018). Distinct inflammatory profile underlies pathological increases in creatinine levels associated with Plasmodium vivax malaria clinical severity. PLoS neglected tropical diseases, 12(3), e0006306. Assay: Heme in human blood.
Cueno, M. E., & Ochiai, K. (2018). Gingival periodontal disease (PD) level-butyric acid affects the systemic blood and brain organ: insights into the systemic inflammation of periodontal disease. Frontiers in immunology 9:1158. Assay: Heme in wistar rat blood.
Mooney, J. P., Barry, A., Goncalves, B. P., Tiono, A. B., Awandu, S. S., Grignard, L. & Riley, E. M. (2018). Haemolysis and haem oxygenase-1 induction during persistent “asymptomatic” malaria infection in Burkinabe children. Malaria journal, 17(1), 253. Assay: Heme in human plasma.
Santiago, R. P., Guarda, C. C., Figueiredo, C. V. B., Fiuza, L. M., Aleluia, M. M., Adanho, C. S. A. & Nascimento, V. M. L. (2018). Serum haptoglobin and hemopexin levels are depleted in pediatric sickle cell disease patients. Blood Cells Mol Dis. 72:34-36. Assay: Heme in human blood.
Abhishek, S., Gupta, A. K., & Singh, A. (2017). Kinetic Models Demonstrate Ability of Staphylococcus aureus to Uptake Heme from Beta vulgaris Proteins. Journal of Pure and Applied Microbiology, 11(4), 1713-1719. Assay: Heme in beetroot juice.
Dalko, E., Tchitchek, N., Pays, L., Herbert, F., Cazenave, P. A., Ravindran, B. & Pied, S. (2016). Erythropoietin levels increase during cerebral malaria and correlate with heme, interleukin-10 and tumor necrosis factor-alpha in India. PloS one, 11(7), e0158420. Assay: Heme in human plasma.
Luz, N. F., Balaji, S., Okuda, K., Barreto, A. S., Bertin, J., Gough, P. J. & Chan, F. K. M. (2016). RIPK1 and PGAM5 control Leishmania replication through distinct mechanisms. The Journal of Immunology, 196(12), 5056-5063. Assay: Heme in human plasma.
Ndisang JF, et al (2010). Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats. Endocrinology 151(2):549-60. Assay: Heme in rat plasma.
Ndisang JF, Jadhav A (2010). The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension. American Journal of Physiolgy, Regululatory Integrative and Comparative Physiology. 298(1):R211-23. Assay: Heme in rat tissue.
Aldag C et al (2009). Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine. PNAS 106(14):5481-6. Assay: Heme in bacteria p450 enzymes.
Huang ML et al (2009). Elucidation of the mechanism of mitochondrial iron loading in Friedreich’s ataxia by analysis of a mouse mutant. PNAS 106(38):16381-6. Assay: Heme in mouse heart.
Zwart SR, et al (2009). Body iron stores and oxidative damage in humans increased during and after a 10- to 12-day undersea dive. J Nutr. 139(1):90-5. Assay: Heme in human plasma.
Pamplona, A. et al (2007). Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria. Nature Med. 13(6): 703-710. Assay: Heme in mouse tissue.
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